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KMID : 1009020130110030165
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Clinical Psychopharmacology and Neuroscience
2013 Volume.11 No. 3 p.165 ~ p.167
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Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
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Min A-Ran
Kim Dae-Ho
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Abstract
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We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic.
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KEYWORD
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Blonanserin, Bipolar disorder, Antipsychotic agents, Schizophrenia, Psychotic disorders
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